601 / 602 - Broken
House begins a detox program at Mayfield Psychiatric Hospital to get the vicodin out of his system in an attempt to control his hallucinations. House plans to leave the treatment facility once he is clean, but he is strong-armed into staying by his attending physician, Dr. Darryl Nolan. Dr. Nolan agrees to write a recommendation to reinstate House's medical license only if House agrees to further treatment. When House moves to a new ward in the hospital, he develops a close relationship with his new roommate, Alvie, and Lydia, a frequent visitor who helps House bend the rules. House asks Alvie to help him uncover incriminating information about Dr. Nolan that would allow him to blackmail his way out of the treatment center and convinces Lydia to loan him her car to sneak out a delusional patient in an attempt by House to undermine Dr. Nolan's course of treatment. However, when devastating events ensue, House is humbled into reluctantly accepting help.
603 - Epic Fall
House has surprising news for Cuddy; an ailing video game creator opts for treatments suggested by people on the Internet rather than listening to the doctors; Foreman tries to get House s job.
604 - The Tyrant
When a controversial African politician falls ill, they bring him to Princeton Plainsboro for treatment. The team struggles with whether to help a merciless dictator being subpoenaed for crimes against humanity in his country. Meanwhile, Wilson tries to make peace with a feuding neighbor, but House's prying exacerbates the problem.
605 - Instant Karma
A rich businessman brings his son, who's suffering from stomach pain, to Princeton Plainsboro, and believes he's a victim of his wealthy position and success.
606 - Brave Heart
A dying patient insists that he has the same disease affecting his heart that killed his father and grandfather at the age of 40. Meanwhile, House discovers that he has a hearing problem while trying to duck student rounds.
607 - Known Unknowns
House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.