401 - Alone
With his diagnostic team gone, House tries to diagnose a young woman who survived an office building collapse. With the condition getting worse, Cuddy puts pressure on House to hire a new team, but instead attempts a differential diagnosis with help from the janitor.
402 - The Right Stuff
House is secretly trying to treat a fighter pilot who is a candidate for NASA's astronaut training program. Her diagnosis will be the test to choose which ones of the 40 applicants are going to take the empty spots in his team.
403 - 97 Seconds
The candidates are now two teams of five women and five men, competing on diagnosing and treating a wheelchair-bound man. Meanwhile House does experiments on himself to test what happens after death, and Foreman, at another hospital, is treating his team in a House-like manner.
404 - Guardian Angels
House finds that some of his own fellowship students will do whatever it takes, when they deal with a woman who believes she can talk to the dead.
405 - Mirror Mirror
House deals with a patient who mirrors the personality of anyone he meets. Meanwhile, Foreman is put in charge of overseeing the fellowship candidates.
406 - Whatever It Takes
Based on practically no information and no medical history about a mystery patient sent by the CIA, House is using some unorthodox methods to diagnose and treat him. Meanwhile the remaining candidates are questioning Foreman's judgment.
407 - Ugly
A film crew and the candidates are following around House distracting him while he is trying to diagnose a teenager who suffers from a heart attack prior to a serious plastic surgery.
408 - You Don't Want to Know
House treats a magician but comes to believe he's faking illness to cover up his own incompetence. Meanwhile, House pits the fellows against each other in his version of an immunity challenge.
409 - Games
Under Cuddy's pressure to choose his team, House gives the candidates a case of a former punk rock star who is a drug user. Whoever diagnoses the patient is going to have a future as a member of House's team.
410 - It's A Wonderful Life
A mother's sudden paralysis during a indoor rock-climbing incident leaves her daughter injured, and House's new team looking for a cure. Meanwhile, House organizes his new recruits' Secret Santa gift exchange... with a few twists of his own.
411 - Frozen
When Dr. Cate Milton (guest star Mira Sorvino), a psychiatrist trapped at the South Pole and the research station's only doctor, becomes ill in the middle of her assignment, she and Dr. House are thrust into a long-distance relationship of sorts. Unable to get Cate out or any additional medical supplies to the South Pole station, House and his team must resort to treating her via webcam.
412 - Don't Ever Change
House and his team must diagnose a Jewish bride who is taken ill at her wedding. However, House is more interested in analyzing Wilson's relationship with his new girlfriend.
413 - No More Mr. Nice Guy
House suspects an emergency room patient has a bigger problem than the E.R. initially diagnosed based on the fact that the patient is too nice. A skeptical House questions the patient's sunny disposition as the team tries to get to the bottom of his illness, but disagrees with House that niceness is a symptom. Meanwhile, House and Amber are at odds about how much time they each get to spend with Wilson, and Cuddy demands House give his team performance reviews.
414 - Living the Dream
House is convinced one of the actors on his favorite soap opera (guest star Jason Lewis) "Prescription Passion" has a serious medical condition after observing his symptoms on television. House decides to intervene and take matters into his own hands, but both the actor and House's own team dismiss House's assessment and do not believe there is anything wrong with him. Meanwhile, much to House's delight, Amber and Wilson have their first argument, and Cuddy tries to keep up appearances when an inspector makes an unexpected visit to Princeton-Plainsboro.
415 - House's Head
House finds himself dazed, confused and covered in blood after surviving a bus accident that left dozens seriously injured. Unable to clearly recall the events leading up to the crash due to his head injuries, House becomes convinced through his flashbacks that a fellow bus passenger was exhibiting signs of a deadly illness prior to the crash. Much to the team's dismay, House pushes through the pain of his own injuries, desperate to piece together the fragments of his shattered memory in order to save someone who might not even know he or she could be dying.
416 - Wilson's Heart
Clues inside House's head hold the key to Amber's condition, and House's friendship with Wilson is tested beyond limits as murky memories from the bus accident the night before threaten to change their lives forever.
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